StrongSaffron
How Saffron's Crocin Targets Serotonin and BDNF Pathways for Mood
A Mechanism-First Deep Dive into Saffron's Neurobiological Effects and Clinical Impact
9 min · 8 sources
Aviado Research Library
Because “studies show” isn’t enough.
270 papers, tiered on a transparent rubric. Read the evidence your supplement rests on — before you swallow it.
270 studies84 supplements10 health goalsLast re-review Jul 2, 2026
Explore research pillars
Editor's picks
Reviewed by Aviado ResearchBrowse all
StrongGaba
GABA's Sleep Architecture Effect: Slow-Wave Enhancement Via GABAA Receptors
How GABA Supplementation Alters Sleep Stages and Efficiency Through Receptor Mechanisms
10 min · 12 sources
StrongHyaluronic Acid
How Hyaluronic Acid's Molecular Weight Drives Opposing Inflammatory Signals
Understanding the Size-Dependent Effects of Hyaluronic Acid on Human Inflammation and Skin Hydration
9 min · 8 sources
Latest research
Updated weeklyFull archive →
Krill Oil · Knowledge BasePreliminary
Krill Oil Reliably Cuts Triglycerides—But Leaves Cholesterol Untouched: What That Split Tells You About Your Own Response
A Deep Dive into the Biomarker-Specific Effects and Personalizable Value of Krill Oil Supplementation
7 min · 8 sources
Spirulina · Knowledge BasePreliminary
Spirulina's Effect on Liver Enzymes Is Fast and Measurable — But Only If Your Baseline Is Elevated
Why Your Liver Panel Predicts Spirulina's True Impact
7 min · 9 sources
Vitamin D3 · Knowledge BasePreliminary
Vitamin D Works Differently Depending on What's Wrong With You: The Baseline-Dependency That Changes Everything
Why your starting vitamin D level determines whether supplementation will help or do nothing
7 min · 11 sources
Vitamin B6 · Knowledge BasePreliminary
Your PLP Level Is a Hidden Report Card on Inflammation, Cancer Risk, and Metabolic Health — Most People Have Never Tested It
9 min · 13 sources
Vitamin A · Knowledge BasePreliminary
Vitamin A's Hidden Role in Thyroid Function: Why Your TSH Might Be Off Without Knowing It
8 min · 9 sources
Sage Extract · Knowledge BasePreliminary
Sage Extract Cuts LDL by 35% in 3 Months — But Only Some People See the Glucose Drop
New RCTs reveal a lipid-lowering edge, but glucose effects depend on your metabolic profile
8 min · 8 sources
L Citrulline · Knowledge BasePreliminary
L-Citrulline Drops Blood Pressure Up to 9 mmHg — But Only in the Right People at the Right Time
8 min · 12 sources
Pomegranate Extract · Knowledge BasePreliminary
Pomegranate's Anti-Inflammatory Effect Is Real — But Only If You're Actually Inflamed
Personalizing Pomegranate Extract: Why Baseline Inflammation Levels Decide Whether You’ll Benefit
8 min · 11 sources
Chlorella · Knowledge BasePreliminary
Chlorella Cuts LDL by 8 mg/dL on Average — But Individual Response Varies Wildly: How to Know If You're a Responder
8 min · 13 sources
Browse by health goal
10 domains · v2.7 rubricAll categories →
Metabolic Health
86 articles · Berberine · Vitamin B6 · Zinc
Cardiovascular & Circulation
85 articles · Omega 3 · Coq10 · Taurine
Brain, Mood & Cognitive Performance
96 articles · Omega 3 · Curcumin · Ashwagandha
Sleep & Recovery
43 articles · Magnesium · Ashwagandha · L Citrulline
Hormonal Health
44 articles · Black Cohosh · Ashwagandha · Tongkat Ali
Muscle, Bone & Joint
67 articles · Creatine · Coq10 · Ashwagandha
Immune System Health & Inflammation
88 articles · Vitamin D3 · Vitamin C · Curcumin
Cellular Longevity & Healthy Aging
55 articles · Nmn · Coq10 · Pqq
Advanced
Gut & Microbiome
31 articles · Probiotics · Berberine · Green Tea Extract
Advanced
Skin, Hair & Collagen
11 articles · Collagen · Vitamin C · Biotin
Explore by pillar
Goal-level hubs that cluster the evidence — and the biomarkers that connect them.
How we tier evidence
Every claim gets the same rubric.
We don’t rate supplements — we rate claims about supplements. A single ingredient can earn Strong evidence for one benefit and Insufficient for another. The tier tells you how seriously to take a specific conclusion, not the molecule in general.
Strong
69 studiesAt least two concordant RCTs with low-to-moderate risk of bias, or a high-certainty GRADE meta-analysis. This is where we feel confident saying yes.
Moderate
26 studiesOne well-designed RCT plus replicated observational data. The signal is real; the effect size isn’t locked down.
Preliminary
175 studiesEarly human data, mixed results, or a single trial. We report it, but we don’t bet the farm on it.
Insufficient
Animal-only studies, mechanism-only claims, or anecdote. We index these so you know they exist, not so you swallow them.
Listen by health goal
Curated evidence reviews for the commute
Brain, Mood & Cognitive Performance
12 featured · ~185 min
- Zinc — How Zinc Ions Block Inflammatory Cascades via NF-κB and Cytokine Control
- Vitamin B Complex — How B-Complex Vitamins Lower Homocysteine Through Methylation Pathways
- Vitamin A — How Vitamin A's Retinoid Pathway Controls Iron Transport and Hemoglobin
- +24 more in this goal
Cardiovascular & Circulation
12 featured · ~176 min
- Zinc — How Zinc Ions Block Inflammatory Cascades via NF-κB and Cytokine Control
- Vitamin B6 — How Vitamin B6 Converts to PLP to Power 150+ Enzyme Reactions
- Vitamin B Complex — How B-Complex Vitamins Lower Homocysteine Through Methylation Pathways
- +19 more in this goal
Immune System Health & Inflammation
12 featured · ~195 min
- Zinc — How Zinc Ions Block Inflammatory Cascades via NF-κB and Cytokine Control
- Curcumin — How Curcumin's Active Compounds Target Nrf2 to Boost Cellular Antioxidants
- Astaxanthin — Astaxanthin for Oxidative Stress: Benefits, Mechanism & Dosing
- +18 more in this goal
Metabolic Health
12 featured · ~187 min
- Zinc — How Zinc Ions Block Inflammatory Cascades via NF-κB and Cytokine Control
- Vitamin B6 — How Vitamin B6 Converts to PLP to Power 150+ Enzyme Reactions
- Astaxanthin — Astaxanthin for Oxidative Stress: Benefits, Mechanism & Dosing
- +17 more in this goal
Cellular Longevity & Healthy Aging
12 featured · ~185 min
- Vitamin B6 — How Vitamin B6 Converts to PLP to Power 150+ Enzyme Reactions
- Curcumin — How Curcumin's Active Compounds Target Nrf2 to Boost Cellular Antioxidants
- Astaxanthin — Astaxanthin for Oxidative Stress: Benefits, Mechanism & Dosing
- +15 more in this goal
Muscle, Bone & Joint
12 featured · ~204 min
- Curcumin — How Curcumin's Active Compounds Target Nrf2 to Boost Cellular Antioxidants
- Ashwagandha — Ashwagandha Is Not Just an Adaptogen: What Its Molecules Actually Do
- Collagen — Why Your Collagen Supplement Probably Isn't Working (And How to Tell)
- +14 more in this goal