Aviado Research · Pillar
Cardiovascular & Circulation
What the literature actually shows about supporting heart, vessels, and lipid handling — sorted by evidence tier, not by what’s loudest in marketing. Useful whether you track lipids on a dashboard or just want to age well.
44 supplements·84 articles·3 biomarkers·Last reviewed
Biomarkers in this pillar
Start from a number.
Each biomarker clusters the supplements and articles with measurable impact on that marker. Drill in for ranges, mechanisms, and what the evidence actually moves.
Lipid Handling
Apo-B
Apolipoprotein B — count of atherogenic particles. The single most informative lipid number; targets vary with risk profile.
Strong evidence→
Cardiovascular Inflammation
hs-CRP
High-sensitivity C-reactive protein. > 3 mg/L flags systemic inflammation that accelerates plaque progression.
Moderate evidence→
Vascular Function
Homocysteine
Amino acid elevated in B-vitamin deficiency. > 11 µmol/L associated with vascular damage; responsive to B-complex sufficiency.
Moderate evidence→
Latest in Cardiovascular & Circulation
What's new.
Krill OilPreliminary
Krill Oil Reliably Cuts Triglycerides—But Leaves Cholesterol Untouched: What That Split Tells You About Your Own Response
Knowledge Base · 7 min · 8 sources
Sage ExtractPreliminary
Sage Extract Cuts LDL by 35% in 3 Months — But Only Some People See the Glucose Drop
Knowledge Base · 8 min · 8 sources
L CitrullinePreliminary
L-Citrulline Drops Blood Pressure Up to 9 mmHg — But Only in the Right People at the Right Time
Knowledge Base · 8 min · 12 sources
Sub-theme01
Lipid Handling
Apo-B, LDL particle count, triglyceride-to-HDL ratio, and the supplements with replicated effects on each. Where the diet-vs-supplement debate has the cleanest evidence base.
Krill OilPreliminary
Krill Oil Reliably Cuts Triglycerides—But Leaves Cholesterol Untouched: What That Split Tells You About Your Own Response
Knowledge Base · 7 min · 8 sources
Sage ExtractPreliminary
Sage Extract Cuts LDL by 35% in 3 Months — But Only Some People See the Glucose Drop
Knowledge Base · 8 min · 8 sources
ChlorellaPreliminary
Chlorella Cuts LDL by 8 mg/dL on Average — But Individual Response Varies Wildly: How to Know If You're a Responder
Knowledge Base · 8 min · 13 sources
Sub-theme02
Vascular Function
Endothelial reactivity, nitric-oxide pathways, arterial stiffness. The downstream of metabolic and inflammatory state — and where the reversibility data is most encouraging.
FolatePreliminary
How Folate's One-Carbon Pathway Controls Insulin, Inflammation & Vessels
Mechanism of Action · 9 min · 10 sources
Cardiovascular BiomarkersPreliminary
The Biomarker Cascade: How Your Heart Sends Distress Signals in a Specific Order — And Why Most People Only Get Tested When It's Almost Too Late
Explainer · 5 min · 7 sources
Vitamin K2Preliminary
How Vitamin K2 Activates Gla Proteins to Control Calcium Flow
Mechanism of Action · 9 min · 18 sources
Sub-theme03
Blood Pressure
What actually moves systolic and diastolic numbers in a clinically meaningful way. Most over-the-counter claims here are smaller than a mediocre walking habit.
L CitrullinePreliminary
L-Citrulline Drops Blood Pressure Up to 9 mmHg — But Only in the Right People at the Right Time
Knowledge Base · 8 min · 12 sources
L ArgininePreliminary
The L-Arginine Paradox: Why Meta-Analyses Contradict Each Other—and What That Means for Your Blood Pressure
Knowledge Base · 8 min · 11 sources
ButyratePreliminary
Your Gut's Butyrate Signal Predicts Whether Supplementation Will Work — Here's How to Find Out
Knowledge Base · 7 min · 11 sources
Sub-theme04
Cardiovascular Inflammation
hs-CRP, IL-6, and the chronic low-grade inflammation that drives plaque progression. Heavy overlap with neuroinflammation and metabolic dysregulation.
ZincModerate
How Zinc Ions Block Inflammatory Cascades via NF-κB and Cytokine Control
Mechanism of Action · 9 min · 9 sources
LuteinModerate
How Lutein Blocks Inflammatory Cascades Through Antioxidant Pathways
Mechanism of Action · 9 min · 12 sources
DhaPreliminary
How DHA Directly Integrates Into Cell Membranes to Control Inflammation
Mechanism of Action · 8 min · 8 sources
Sub-theme05
Rhythm & Electrolyte Support
Magnesium, potassium, taurine, and the electrolyte balance that keeps cardiac rhythm steady. Often overlooked, occasionally critical.
Vitamin B ComplexPreliminary
How B-Complex Vitamins Lower Homocysteine Through Methylation Pathways
Mechanism of Action · 9 min · 10 sources
Rhodiola RoseaPreliminary
How Rhodiola's Salidroside Activates AMPK to Boost Cellular Energy
Mechanism of Action · 10 min · 12 sources
Nicotinamide RibosidePreliminary
How Nicotinamide Riboside Boosts NAD+ to Power Cellular Energy Systems
Mechanism of Action · 9 min · 15 sources
All supplements in this pillar
Ranked by evidence tier.
Every supplement with published evidence for Cardiovascular & Circulation. Tiering reflects the strength of the primary literature, not market popularity.
Moderate
Preliminary
- Coq102 articles
- Cordyceps2 articles
- Epa2 articles
- L Citrulline2 articles
- Niacin2 articles
- Rhodiola Rosea2 articles
- Taurine2 articles
- Vitamin B Complex2 articles
- Acetyl L Carnitine1 article
- Astaxanthin1 article
- Astragalus1 article
- Berberine1 article
- Bifidobacterium1 article
- Biotin1 article
- Butyrate1 article
- Calcium1 article
- Chlorella1 article
- Dha1 article
- Folate1 article
- Gaba1 article
- Inulin1 article
- Krill Oil1 article
- L Arginine1 article
- L Carnitine1 article
- Lactobacillus1 article
- Magnesium1 article
- Melatonin1 article
- Melissa Officinalis1 article
- Milk Thistle1 article
- N Acetyl Cysteine1 article
- Nicotinamide Riboside1 article
- Olive Leaf Extract1 article
- Omega 31 article
- Omega 3 Fatty Acids1 article
- Pqq1 article
- Resveratrol1 article
- Sage Extract1 article
- Sulforaphane1 article
- Vitamin B61 article
- Vitamin C1 article
- Vitamin D1 article
- Vitamin K21 article
- Zinc1 article
Insufficient
No supplements in this tier yet.
Complete index
Every article in Cardiovascular & Circulation
All 84 published Aviado Research articles in this pillar, linked in one place.
- PreliminaryKrill Oil Reliably Cuts Triglycerides—But Leaves Cholesterol Untouched: What That Split Tells You About Your Own ResponseKnowledge Base
- PreliminarySage Extract Cuts LDL by 35% in 3 Months — But Only Some People See the Glucose DropKnowledge Base
- PreliminaryL-Citrulline Drops Blood Pressure Up to 9 mmHg — But Only in the Right People at the Right TimeKnowledge Base
- PreliminaryChlorella Cuts LDL by 8 mg/dL on Average — But Individual Response Varies Wildly: How to Know If You're a ResponderKnowledge Base
- PreliminaryThe L-Arginine Paradox: Why Meta-Analyses Contradict Each Other—and What That Means for Your Blood PressureKnowledge Base
- PreliminaryYour Gut's Butyrate Signal Predicts Whether Supplementation Will Work — Here's How to Find OutKnowledge Base
- PreliminaryOlive Leaf Extract Works for Blood Pressure — But Only in the Right People: What Responders Have in CommonKnowledge Base
- ModerateHow Zinc Ions Block Inflammatory Cascades via NF-κB and Cytokine ControlMechanism of Action
- PreliminaryHow Vitamin K2 Activates Gla Proteins to Control Calcium FlowMechanism of Action
- PreliminaryHow Vitamin B6 Converts to PLP to Power 150+ Enzyme ReactionsMechanism of Action
- PreliminaryHow B-Complex Vitamins Lower Homocysteine Through Methylation PathwaysMechanism of Action
- PreliminaryHow Rhodiola's Salidroside Activates AMPK to Boost Cellular EnergyMechanism of Action
- PreliminaryHow Nicotinamide Riboside Boosts NAD+ to Power Cellular Energy SystemsMechanism of Action
- PreliminaryCoQ10's Dual Role: Electron Transport Plus Ferroptosis ProtectionMechanism of Action
- PreliminaryTaurine Targets Calcium Channels and GABA Receptors for Blood Pressure ControlMechanism of Action
- PreliminaryHow Niacin's GPR109A Receptor Triggers Dual Lipid and Inflammation ControlMechanism of Action
- ModerateHow Lutein Blocks Inflammatory Cascades Through Antioxidant PathwaysMechanism of Action
- PreliminaryL-Citrulline Bypasses Arginine to Boost Nitric Oxide for Blood PressureMechanism of Action
- PreliminaryCordycepin Activates AMPK to Reduce Inflammation While Boosting HDLMechanism of Action
- PreliminaryL-Carnitine's Dual Pathway: Beta-Oxidation Enhancement vs TMAO ProductionMechanism of Action
- PreliminaryHow Inulin's Gut-Derived SCFAs Drive Metabolic & Inflammatory ChangesMechanism of Action
- PreliminaryEPA Lowers Triglycerides Through VLDL Particle ReductionMechanism of Action
- PreliminaryHow DHA Directly Integrates Into Cell Membranes to Control InflammationMechanism of Action
- StrongGABA's Sleep Architecture Effect: Slow-Wave Enhancement Via GABAA ReceptorsMechanism of Action
- PreliminaryHow Folate's One-Carbon Pathway Controls Insulin, Inflammation & VesselsMechanism of Action
- PreliminaryHow Biotin Activates Carboxylase Enzymes to Control Fat and GlucoseMechanism of Action
- PreliminaryHow Astragalus Polysaccharides Reset Inflammatory Balance Through IL-6/IL-10Mechanism of Action
- PreliminaryCalcium's Hidden Metabolic Job: Why Your HDL, Triglycerides, and Blood Pressure All Respond Differently to the Same DoseKnowledge Base
- PreliminaryNiacin Raises HDL and Lowers Lp(a) — But Also Worsens Insulin Resistance: How to Know If the Trade-Off Works for YouKnowledge Base
- PreliminaryMilk Thistle's Hidden Metabolic Upgrade: The Liver Supplement That Also Drops Blood Sugar 22 mg/dL and Rewires Insulin ResistanceKnowledge Base
- PreliminaryWhy Your Magnesium Supplement May Be Working—Just Not Where You're LookingKnowledge Base
- PreliminaryVitamin C Works Differently If You Have Type 2 Diabetes — And the Gap Is EnormousKnowledge Base
- PreliminaryCordyceps Isn't an Athletic Supplement — It's a Kidney Protection Tool Most People Are IgnoringKnowledge Base
- PreliminaryNAC's Inflammation Effect Varies 10-Fold Across Studies — Your Baseline Oxidative Stress Determines Whether It WorksKnowledge Base
- PreliminaryYour Genetics Determine Whether Sulforaphane Works at All — Here's How to Find OutKnowledge Base
- PreliminaryBerberine Works — But Only If Your Gut Can Activate It: The Microbiome Key Most Users Are MissingKnowledge Base
- PreliminaryMelatonin Is Not Just a Sleep Hormone — It's a Metabolic Regulator With a Dose-Timing ProblemKnowledge Base
- PreliminaryWhy Two People Taking the Same Vitamin D Dose Can End Up With Completely Different Blood LevelsKnowledge Base
- PreliminaryTaurine's Blood Pressure Effect Is Real — But Only If You're a Responder. Here's How to Find OutKnowledge Base
- PreliminaryResveratrol Works — But Only If You Have the Right Metabolic ProfileKnowledge Base
- PreliminaryZinc's Benefits Are Real — But Only If You're Actually DeficientKnowledge Base
- PreliminaryCoQ10 Absorption Is Highly Variable — Your Form, Fat Intake, and Genetics May Determine Whether You're Getting Any BenefitKnowledge Base
- PreliminaryCellular Longevity for Men 18-39: The Science and Strategy to Age Well—Starting NowKnowledge Base
- PreliminaryHormonal Health After 40: Turning the Most Overlooked Transition Into Your Greatest Health OpportunityKnowledge Base
- PreliminaryMuscle, Bone & Joint Health After 40: Your Comprehensive Guide to Staying Strong, Mobile, and IndependentKnowledge Base
- PreliminaryHormonal Health in Your 20s and 30s: Why Your Menstrual Cycle Is Your Fifth Vital SignKnowledge Base
- PreliminaryPeak Mental Performance: The Comprehensive Guide for Men 18–39Knowledge Base
- PreliminaryThe Insulin Resistance Spectrum: Why 'Normal' Glucose Can Hide a Decade of Metabolic RiskKnowledge Base
- PreliminaryYour Heart Health Advantage: A Comprehensive Guide for Men in Their 20s and 30sKnowledge Base
- PreliminaryDrug-Supplement Interactions: What Aviado’s Warnings Actually Mean (And What To Do)Knowledge Base
- PreliminaryCardiovascular Health After 40: Why Midlife Women Need a New PlaybookKnowledge Base
- PreliminaryMetabolic Health in Women 18-39: Beyond Calories, Into HormonesKnowledge Base
- PreliminaryCardiovascular Mastery for Men 40–65: Precision Strategies to Outpace Heart DiseaseKnowledge Base
- PreliminaryThe Carnitine Responder Paradox: Why Your Baseline Metabolic State Predicts Whether ALC Works For YouKnowledge Base
- PreliminaryYour Omega-3 Index: The One Number That Explains Why Fish Oil Works for Some People and Does Nothing for OthersKnowledge Base
- StrongYour Heart Health Advantage: A Comprehensive Guide for Men in Their 20s and 30sKnowledge Base
- StrongCardiovascular Health After Menopause: The Risk Women Were Never Warned AboutKnowledge Base
- StrongCardiovascular Health After 65: Protecting the Engine When the Stakes Are HighestKnowledge Base
- StrongThe Heart Disease Blind Spot: A Comprehensive Guide to Cardiovascular Health for Women 18–39Knowledge Base
- StrongCardiovascular Health After 40: Why Midlife Women Need a New PlaybookKnowledge Base
- StrongCardiovascular Mastery for Men 40–65: Precision Strategies to Outpace Heart DiseaseKnowledge Base
- PreliminaryThe Lipid Biomarker Decision Tree: Why Your Standard Cholesterol Panel Misses Half the StoryExplainer
- PreliminaryThe Four Blood Signals That Predict Brain Aging — And Why Most Doctors Don't Test ThemExplainer
- PreliminaryThe HPA Axis Traffic Switch: How Your Body Chooses Between Thyroid, Stress, and Sex Hormones — and What Your Biomarkers Reveal About That ChoiceExplainer
- PreliminaryThe Biomarker Cascade: How Your Heart Sends Distress Signals in a Specific Order — And Why Most People Only Get Tested When It's Almost Too LateExplainer
- PreliminaryWhy Astaxanthin's Cholesterol Research Contradicts Itself — And What That Means for Your DoseKnowledge Base
- PreliminaryRhodiola's Cortisol Effect Disappears in Some People — Here's How to Know If You're One of ThemKnowledge Base
- PreliminaryLemon Balm's Cholesterol Benefits Are Real—But Only If You're Taking the Right FormKnowledge Base
- PreliminaryYour B-Complex Lowers Homocysteine—But That May Not Be Enough to Protect Your Heart or BrainKnowledge Base
- PreliminaryEPA vs DHA: The Ratio in Your Fish Oil Capsule Changes Everything — And Most People Are Taking the Wrong OneKnowledge Base
- PreliminaryYour Lactobacillus Strain Is the Variable: Why Most Probiotic Research Misses the PointKnowledge Base
- PreliminaryThe Bifidobacterium Paradox: Same Probiotic, Opposite Effects on LDL and HbA1c Depending on Which Strain and Who You AreKnowledge Base
- PreliminaryPQQ May Be the Missing Piece in Your Mitochondria Strategy — But Only If You're Already InflamedKnowledge Base
- PreliminaryWhy Your LDL Target Should Be Personal, Not UniversalKnowledge Base
- PreliminaryGABA Supplements Can't Cross the Blood-Brain Barrier — So Why Do Some People Swear By Them?Knowledge Base
- ModerateThe metformin interaction that makes berberine more complicated for people already on diabetes medicationKnowledge Base
- PreliminaryThe omega-3 index as a status marker: what the proven blood response tells you that dose labels cannotKnowledge Base
- ModerateTaurine May Lower Blood Pressure and Improve Metabolic Health: What the Research SaysKnowledge Base
- ModerateBerberine Lowers Blood Sugar and Cholesterol: What the Research Really SaysKnowledge Base
- ModerateOmega-3: What Science Really Says About Heart, Brain, and Fertility BenefitsKnowledge Base
- StrongBest Supplements for LDL Cholesterol: What the Evidence Actually ShowsKnowledge Base
- StrongBest Supplements for Homocysteine: What the Evidence Actually ShowsKnowledge Base
- ModerateBest Supplements for C-Reactive Protein (Inflammation): What the Evidence Actually ShowsKnowledge Base
- ModerateCoQ10: The Cellular Fuel Your Body Makes Less of Every Decade — and What the Evidence Says About Replacing ItKnowledge Base
Frequently asked
Questions Aviado Research hears on this pillar.
Why does Aviado lead with Apo-B instead of LDL-C?
Editorial draft pending — Apo-B counts atherogenic particles directly; LDL-C estimates cholesterol per particle and can underestimate risk in metabolic dysfunction. Brief, citation-light, no testing-imperative.
How do evidence tiers apply to this pillar specifically?
Editorial draft pending — Restate the 4-tier rubric with cardiovascular examples. Note that hard outcome trials (MACE, mortality) are weighted more heavily than surrogate-endpoint trials when the literature offers both.
Where do supplements fit alongside statins, PCSK9s, or BP meds?
Editorial draft pending — Adjunct framing only. Aviado does not position supplements as substitutes for prescribed therapy. Cross-link to /methodology/ for how interaction risks are flagged.
How often is this pillar refreshed?
Editorial draft pending — Quarterly cadence; out-of-band re-reviews triggered by new meta-analyses, regulatory action (e.g. red-yeast-rice rulings), or safety signals.