Cardiovascular & Circulation
What the literature actually shows about supporting heart, vessels, and lipid handling — sorted by evidence tier, not by what’s loudest in marketing. Useful whether you track lipids on a dashboard or just want to age well.
Start from a number.
Each biomarker clusters the supplements and articles with measurable impact on that marker. Drill in for ranges, mechanisms, and what the evidence actually moves.
Apolipoprotein B — count of atherogenic particles. The single most informative lipid number; targets vary with risk profile.
High-sensitivity C-reactive protein. > 3 mg/L flags systemic inflammation that accelerates plaque progression.
Amino acid elevated in B-vitamin deficiency. > 11 µmol/L associated with vascular damage; responsive to B-complex sufficiency.
What's new.
Versioned Article
Krill Oil Reliably Cuts Triglycerides—But Leaves Cholesterol Untouched: What That Split Tells You About Your Own Response
Sage Extract Cuts LDL by 35% in 3 Months — But Only Some People See the Glucose Drop
Lipid Handling
Apo-B, LDL particle count, triglyceride-to-HDL ratio, and the supplements with replicated effects on each. Where the diet-vs-supplement debate has the cleanest evidence base.
Krill Oil Reliably Cuts Triglycerides—But Leaves Cholesterol Untouched: What That Split Tells You About Your Own Response
Sage Extract Cuts LDL by 35% in 3 Months — But Only Some People See the Glucose Drop
Chlorella Cuts LDL by 8 mg/dL on Average — But Individual Response Varies Wildly: How to Know If You're a Responder
Vascular Function
Endothelial reactivity, nitric-oxide pathways, arterial stiffness. The downstream of metabolic and inflammatory state — and where the reversibility data is most encouraging.
How Folate's One-Carbon Pathway Controls Insulin, Inflammation & Vessels
The Biomarker Cascade: How Your Heart Sends Distress Signals in a Specific Order — And Why Most People Only Get Tested When It's Almost Too Late
How Vitamin K2 Activates Gla Proteins to Control Calcium Flow
Blood Pressure
What actually moves systolic and diastolic numbers in a clinically meaningful way. Most over-the-counter claims here are smaller than a mediocre walking habit.
L-Citrulline Drops Blood Pressure Up to 9 mmHg — But Only in the Right People at the Right Time
The L-Arginine Paradox: Why Meta-Analyses Contradict Each Other—and What That Means for Your Blood Pressure
Your Gut's Butyrate Signal Predicts Whether Supplementation Will Work — Here's How to Find Out
Cardiovascular Inflammation
hs-CRP, IL-6, and the chronic low-grade inflammation that drives plaque progression. Heavy overlap with neuroinflammation and metabolic dysregulation.
How Zinc Ions Block Inflammatory Cascades via NF-κB and Cytokine Control
How Lutein Blocks Inflammatory Cascades Through Antioxidant Pathways
How DHA Directly Integrates Into Cell Membranes to Control Inflammation
Rhythm & Electrolyte Support
Magnesium, potassium, taurine, and the electrolyte balance that keeps cardiac rhythm steady. Often overlooked, occasionally critical.
How B-Complex Vitamins Lower Homocysteine Through Methylation Pathways
How Rhodiola's Salidroside Activates AMPK to Boost Cellular Energy
How Nicotinamide Riboside Boosts NAD+ to Power Cellular Energy Systems
Ranked by evidence tier.
Every supplement with published evidence for Cardiovascular & Circulation. Tiering reflects the strength of the primary literature, not market popularity.
- Coq102 articles
- Cordyceps2 articles
- Epa2 articles
- L Citrulline2 articles
- Magnesium2 articles
- Niacin2 articles
- Rhodiola Rosea2 articles
- Taurine2 articles
- Vitamin B Complex2 articles
- Acetyl L Carnitine1 article
- Astaxanthin1 article
- Astragalus1 article
- Berberine1 article
- Bifidobacterium1 article
- Biotin1 article
- Butyrate1 article
- Calcium1 article
- Chlorella1 article
- Dha1 article
- Folate1 article
- Gaba1 article
- Inulin1 article
- Krill Oil1 article
- L Arginine1 article
- L Carnitine1 article
- Lactobacillus1 article
- Melatonin1 article
- Melissa Officinalis1 article
- Milk Thistle1 article
- N Acetyl Cysteine1 article
- Nicotinamide Riboside1 article
- Olive Leaf Extract1 article
- Omega 31 article
- Omega 3 Fatty Acids1 article
- Pqq1 article
- Resveratrol1 article
- Sage Extract1 article
- Sulforaphane1 article
- Vitamin B61 article
- Vitamin C1 article
- Vitamin D1 article
- Vitamin K21 article
- Zinc1 article
Questions Aviado Research hears on this pillar.
Why does Aviado lead with Apo-B instead of LDL-C?
Editorial draft pending — Apo-B counts atherogenic particles directly; LDL-C estimates cholesterol per particle and can underestimate risk in metabolic dysfunction. Brief, citation-light, no testing-imperative.
How do evidence tiers apply to this pillar specifically?
Editorial draft pending — Restate the 4-tier rubric with cardiovascular examples. Note that hard outcome trials (MACE, mortality) are weighted more heavily than surrogate-endpoint trials when the literature offers both.
Where do supplements fit alongside statins, PCSK9s, or BP meds?
Editorial draft pending — Adjunct framing only. Aviado does not position supplements as substitutes for prescribed therapy. Cross-link to /methodology/ for how interaction risks are flagged.
How often is this pillar refreshed?
Editorial draft pending — Quarterly cadence; out-of-band re-reviews triggered by new meta-analyses, regulatory action (e.g. red-yeast-rice rulings), or safety signals.
Heart and vessels, tiered honestly.
Browse every article in this pillar filtered by evidence tier, supplement, biomarker, or sub-theme.
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